ABSTRACT
Resumen OBJETIVOS: Determinar la repercusión de la diabetes pregestacional, con hiperglucemias moderadas, en el rendimiento reproductivo de la rata, crecimiento, desarrollo y morfología embrionaria en ratas Wistar. MATERIALES Y MÉTODOS: Estudio longitudinal, prospectivo y experimental efectuado en la Unidad de Investigaciones Biomédicas de la Universidad de Ciencias Médicas de Villa Clara, Cuba, en un modelo de diabetes moderada inducida neonatalmente a crías hembras de ratas Wistar de dos días de nacidas mediante la administración subcutánea de 100 mg/kg de peso corporal de estreptozotocina en una única dosis. A los 120 días de nacidas, las ratas de ambos grupos de experimentación (diabético y control) se aparearon con machos sanos. Se determinaron el peso y la glucemia durante la gestación y a los 11.5 días se practicó la cesárea. Se analizaron las variables del rendimiento reproductivo materno y de crecimiento, desarrollo y morfología externa en los embriones. Acorde con los desenlaces se utilizaron pruebas no paramétricas para el análisis de las variables cuantitativas y la prueba de χ2 para las variables cualitativas. RESULTADOS: La hiperglucemia moderada pregestacional provocó modificaciones en la ganancia de peso de la madre, la cantidad de reabsorciones, sitios de implantación, pérdidas preimplantación y eficiencia de implantación, así como en la morfología, talla y cantidad de somitas en los embriones. CONCLUSIONES: La diabetes moderada pregestacional alteró el rendimiento reproductivo materno y el crecimiento y desarrollo intrauterino de la descendencia en etapa embrionaria. La embriopatía diabética se manifestó, además, con malformaciones del sistema nervioso central.
Abstract OBJECTIVES: Diabetes mellitus is one of the most frequent disorders of pregnancy with adverse consequences for the mother and a high risk of diabetic embryopathy in the offspring. The objective of the research was to determine the effect of pregestational diabetes with moderate hyperglycemia on maternal reproductive performance, growth, development and embryonic morphology in Wistar rats. MATERIALS AND METHODS: Longitudinal, prospective and experimental study carried out at the Biomedical Research Unit of the University of Medical Sciences of Villa Clara, Cuba. A model of neonatally induced moderate diabetes was used in female Wistar rat pups two days old, by subcutaneous administration of 100 mg/kg of body weight of streptozotocin in a single dose. At 120 days after birth, rats from both experimental groups (diabetic and control) were mated with healthy males. Weight and glycemia were determined during pregnancy and at 11,5 days the cesarean section was performed. The variables of maternal reproductive performance and of growth, development and external morphology in the embryos were analyzed. According to the results, non-parametric tests were used for the analysis of the quantitative variables and the Chi-square test for the qualitative variables. RESULTS: Moderate pregestational diabetes caused changes in maternal weight gain, number of resorptions, implantation sites, preimplantation loss, and implantation efficiency, as well as in morphology, size, and number of somites in embryos. CONCLUSIONS: Moderate pregestational diabetes altered maternal reproductive performance and intrauterine growth and development of embryonic offspring. Diabetic embryopathy was also manifested by malformations of the central nervous system.
ABSTRACT
BACKGROUND: The recent FDA approval of non-prescription sales of Plan B, an emergency contraceptive method to those 18 years old and over, gives a prominent role to pharmacists in providing timely access to emergency contraception (EC). While this decision affects Puerto Rico, no studies on non-prescription EC in Puerto Rico have been conducted. The purpose of this study is to identify the knowledge, attitudes and practices of a group of pharmacists in Puerto Rico regarding emergency contraceptive pills. METHODS: A cross-sectional descriptive study of a group of pharmacists' knowledge, attitudes, and practices regarding EC was conducted among those who attended the annual convention of the College of Pharmacists of Puerto Rico on August 24-26, 2006. RESULTS: Slightly more than half of pharmacists surveyed (51.4%) supported a law that allows them to dispense EC without a prescription. Yet, overall EC knowledge was low given that the average number of knowledge questions answered correctly was 1.8 (SD+/-1.36) out of 6. Pharmacists who correctly answered knowledge questions about EC, whose pharmacy dispensed EC, and who felt comfortable giving information to a client about EC were significantly more likely to support the non-prescription EC law. CONCLUSION: Knowledge about EC was low among the pharmacists that were surveyed, but there was support for a non-prescription EC policy in Puerto Rico. Increased education efforts are needed in this important group of allied health professionals.
Subject(s)
Contraception, Postcoital , Health Knowledge, Attitudes, Practice , Pharmacists , Cross-Sectional Studies , Female , Humans , Male , Puerto Rico , Surveys and QuestionnairesABSTRACT
Con el incremento de pacientes que sufren enfermedad de Alzheimer el personal de enfermería debe trazar nuevas pautas de trabajo debido al deterioro cerebral que sufre el afectado y la carga que ello implica para sus familiares. El mundo se cuestiona el rol del personal de enfermería por lo que se realizan programas de cuidados especiales para pacientes con enfermedad de Alzheimer. En el presente trabajo se describe la actitud de la enfermera mediante una breve revisión de los problemas relacionados con el manjo de pacientes con demencia tipo Alzheimer y la presentación de un plan de cuidados para este tipo de pacientes(AU)
